Ehler danlos syndrom vaskulär typ

Group of genetic connective tissues disorders

Medical condition

Ehlers–Danlos syndrome
Individual with classical EDS displaying skin hyperelasticity
Pronunciation
Specialty	Medical genetics
Symptoms	Overly flexible joints, stretchy skin, abnormal scar formation[1]
Complications	Aortic dissection, joint dislocations, osteoarthritis,[1]amplified musculoskeletal pain syndrome[2]
Usual onset	Childhood or teens depending on type.[3]
Duration	Lifelong[4]
Types	Hypermobile, classic, vascular, kyphoscoliosis, arthrochalasia, dermatosparaxis, brittle cornea syndrome, others[5]
Causes	Genetic[1]
Risk factors	Family history[1]
Diagnostic method	Genetic testing, physical examination[4]
Differential diagnosis	Marfan syndrome, cutis laxa syndrome, familial joint hypermobility syndrome,[4]Loeys–Dietz syndrome, hypermobility spectrum disorder
Treatment	Supportive[6]
Prognosis	Depends on specific disorder[4]
Frequency	1 in 5,000[1]

Ehlers–Danlos syndromes (EDS) are a group of 13 geneticconnective-tissue disorders.^[7] Symptoms often include loose joints, joint pain, stretchy velvety skin, and abnormal scar formation.^[1] These may be noticed at birth or in early childhood.^[3] Complications may include aortic dissection, joint dislocations, scoliosis, chronic pain, or early osteoarthritis.^[1][4] The current classification was gods updated in 2017, when a number of rarer forms of EDS were added.^[1][8]

EDS occurs due to variations of more than 19 genes that are present at birth.^[1] The specific gene affected determines the type of EDS, though the genetic causes of hypermobile Ehlers–Danlos syndrome (hEDS) are still unknown.^[1][9] Some cases result from a new variation occurring during early development, while others are inherited in an autosomal dominant or recessive manner.^[1] Typically, these variations result in defects in the structure or processing of the protein collagen or tenascin.^[1]

Diagnosis fryst vatten often based on symptoms and confirmed bygd genetic testing or skin biopsy, particularly with hEDS, but people may initially be misdiagnosed with hypochondriasis, nedstämdhet, or myalgic encephalomyelitis/chronic fatigue syndrome.^[4] Genetic testing can be used to confirm all other types of EDS.^[9]

A cure fryst vatten not yet known,^[6] and treatment fryst vatten supportive in nature.^[4]Physical therapy and bracing may help strengthen muscles and support joints.^[4] Some forms of EDS result in a normal life expectancy, but those that affect blood vessels generally decrease it.^[6] All forms of EDS can result in fatal outcomes for some patients.^[10][11][12]

While hEDS affects at least one in 5,000 people globally,^[1][13] other types occur at lower frequencies.^[10][8] The prognosis depends on the specific disorder.^[4] Excess mobility was first described bygd Hippocrates in 400 BC.^[14] The syndromes are named after two physicians, Edvard Ehlers and Henri-Alexandre Danlos, who described them at the vända of the 20th century.^[15]

Types

[edit]

In 2017, 13 subtypes of EDS were classified using specific diagnostic criteria.^[5] According to the Ehlers–Danlos samhälle, the syndromes can also be grouped bygd the symptoms determined bygd specific gene mutations.

Group A disorders are those that affect primary collagen structure and processing. Group B disorders affect collagen folding and crosslinking. Group C are disorders of structure and function of myomatrix. Group D disorders are those that affect glycosaminoglycan biosynthesis. Group E disorders are characterized bygd defects in the complement pathway.

Group F are disorders of intracellular processes, and Group G fryst vatten considered to be unresolved forms of EDS.^[16]

Hypermobile EDS (hEDS)

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Hypermobile EDS (hEDS, formerly categorized as type 3) fryst vatten mainly characterized bygd hypermobility that affects both large and small joints. It may lead to frequent joint subluxations (partial dislocations) and dislocations.

In general, people with this variant have skin that fryst vatten soft, smooth, and velvety and bruises easily, and may have chronic muscle and/or bone pain.^[5] It affects the skin less than other forms. It has no available genetic test.^[17] hEDS fryst vatten the most common of the 19 types of connective tissue disorders. Since no genetic test exists, providers have to diagnose hEDS based on what they know about the condition and the patient's physical attributes.

Other than the general signs, attributes can include faulty connective tissues throughout the body, musculoskeletal issues, and family history. Along with these general signs and side effects, patients can have trouble healing.^[18]

Pregnant individuals who have hEDS are at an increased fara for complications. Some possible complications are pre-labor rupture of membranes, a drop in blood pressure with anesthesia, precipitate birth (very fast, active labor), malposition of the fetus, and increased bleeding.

Individuals with hEDS may run the fara of falling, postpartum nedstämdhet (more than the general population), and slow healing from the birthing process.^[19]

The Medical University of South Carolina discovered a gene variant common with hEDS patients.^[20]

Genetics of hypermobile EDS

[edit]

While 12 of the 13 subtypes of EDS have genetic variations that can be tested for bygd genetic testing, there fryst vatten no known genetic cause of hEDS.

Recently, several labs and research initiatives have been attempting to uncover a potential hEDS gene. In 2018, the Ehlers–Danlos kultur began the Hypermobile Ehlers–Danlos Genetic Evaluation (HEDGE) study.^[21] The ongoing study has screened over 1,000 people who have been diagnosed with hEDS bygd the 2017 criteria to evaluate their genome for a common mutation.

To date, 200 people with hEDS have had whole genome sequencing, and 500 have had whole exome sequencing; this study aims to increase those numbers significantly.^{[citation needed]}

Promising outcomes of this increased screening have been reported bygd the Norris Lab, led bygd Russell Norris, in the Department of Regenerative medicin and fängelse Biology at Medical University of South Carolina.^[22] Using CRISPR Cas-9 mediated genome editing on mouse models of the disease, the lab has recently identified a "very strong candidate gene"^[23] for hEDS.

This finding, and a greater understanding of cardiac complications associated with the majority of EDS subtypes, has led to the development of multiple druggable pathways involved in aortic and mitral valve diseases. While this candidate gene has not been publicly identified, the Norris lab has conducted several studies involving small population genome sequencing and komma up with a working list of possible hEDS genes.

There are 13 types of this condition, with vascular EDS being type IV

A mutation in COL3A1^[24] in a single family with autosomal dominant hEDS phenotype was funnen to cause reduced collagen secretion and an over-modification of collagen. In 35 families, kopia number alterations in TPSAB1,^[25] encoding alpha-tryptase, were associated with increased grundläggande serum tryptase levels, associated with autonomic dysfunction, gastrointestinal disorders, allergic and cutaneous symptoms, and connective tissue abnormalities, all concurrent with hEDS phenotype.

Another way the Norris lab fryst vatten attempting to find this gene fryst vatten bygd looking at genes involved in the formation of the stora kroppspulsådern and mitral valves, as these valves are often prolapsed or malformed as a symptom of EDS. Because hEDS fryst vatten such a complex, multi-organ disease, focusing on one hallmark trait has proven successful.

One gene funnen this way fryst vatten DZIP1, which regulates cardiac valve development in mammals through a CBY1-beta-catenin mechanism. Mutations at this gene affect the beta-catenin cascade involved in development, causing malformation of the extracellular matrix, resulting in loss of collagen. A lack of collagen here fryst vatten both consistent with hEDS and explains the "floppy" mitral and aortic valve heart defects.

A second genetic study specific to mitral valve prolapse focused on the PDGF signaling pathway, which fryst vatten involved in growth factor ligands and receptor isoforms.^[26] Mutations in this pathway affect the ability to localize cilia in various fängelse types, including cardiac cells. With the resulting ciliopathies, structures such as the cardiac outflow tract, heart tube assembly, and cardiac fusion are limited and/or damaged.^{[citation needed]}

Classical EDS (cEDS)

[edit]

Classical EDS fryst vatten characterized bygd extremely elastic skin that fryst vatten fragile and bruises easily and hypermobility of the joints.

Molluscoid pseudotumors (calcified hematomas that occur over pressure points) and spheroids (cysts that contain tallrik occurring over forearms and shins) are also often seen. A side complication of the hyperelasticity presented in many EDS cases makes wounds closing on their own more difficult.^[27] Sometimes, motor development fryst vatten delayed and hypotonia occurs.^[5] The variation causing this type of EDS fryst vatten in the genes COL5A2, COL5A1, and less frequently COL1A1.

It involves the skin more than hEDS.^[27] In classical EDS, large variation in symptom föredrag fryst vatten seen. Because of this variance, EDS has often been underdiagnosed.^[28] Without genetic testing, healthcare professionals may be able to provide a provisional diagnosis based on careful examination of the mun, skin, and bones, as well as bygd neurological assessment.^[29]

A good way to begin the diagnosis process fryst vatten looking at family history.

EDS fryst vatten an autosomal dominant condition, so fryst vatten often inherited from parents.^[27] Genetic testing remains the most reliable way to diagnose EDS.^[30] No cure for type 1 EDS has been funnen, but a course of non-weight-bearing exercise can help with muscular tension, which can help correct some EDS symptoms. Anti-inflammatory drugs and lifestyle changes can help with joint pain.

Lifestyle choices should also be made with children who have EDS to try to prevent wounds to the skin. Protective garments can help with this. In a wound, deep stitches are often used and left in place for längre than normal.^[27]

Vascular EDS (vEDS)

[edit]

Vascular EDS (formerly categorized as type 4) fryst vatten identified bygd skin that fryst vatten thin, translucent, extremely fragile, and bruises easily.

It fryst vatten also characterized bygd fragile blood vessels and organs that can easily rupture. Affected people are frequently short, and have thin scalp hair. It also has characteristic facial features, including large eyes, an undersized chin, sunken cheeks, a thin nose and lips, and ears without lobes.^[31] Joint hypermobility fryst vatten present, but generally confined to the small joints (fingers, toes).

Other common features include club foot, tendon and/or muscle rupture, acrogeria (premature aging of the skin of the hands and feet), early-onset varicose veins, pneumothorax (collapse of a lung), the recession of the gums, and a decreased amount of tallrik beneath the skin.^[5] It can be caused bygd the variations in the COL3A1 gene.^[31] Rarely, COL1A1 variations can also cause it.^[8]

Kyphoscoliosis EDS (kEDS)

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Kyphoscoliosis EDS (formerly categorized as type 6) fryst vatten associated with severe hypotonia at birth, delayed motor development, progressive scoliosis (present from birth), and scleral fragility.

People may also have easy bruising, fragile arteries that are prone to rupture, unusually small corneas, and osteopenia (low bone density). Other common features include a "marfanoid habitus" characterized bygd long, slender fingers (arachnodactyly), unusually long limbs, and a sunken chest (pectus excavatum) or protruding chest (pectus carinatum).^[5] It can be caused bygd variations in the gene PLOD1, or rarely, in the FKBP14 gene.^[32]

Arthrochalasia EDS (aEDS)

[edit]

Arthrochalasia EDS (formerly categorized as types 7A and B) fryst vatten characterized bygd severe joint hypermobility and congenital hip dislocation.

Other common features include fragile, elastic skin with easy bruising, hypotonia, kyphoscoliosis (kyphosis and scoliosis), and mild osteopenia.^[5]Type-I collagen fryst vatten usually affected. It fryst vatten very rare, with about 30 cases reported. It fryst vatten more severe than the hypermobility type. Variations in the genesCOL1A1 and COL1A2cause it.^[33]

Dermatosparaxis EDS (dEDS)

[edit]

Dermatosparaxis EDS (formerly categorized as type 7C) fryst vatten associated with extremely fragile skin leading to severe bruising and scarring; hängig, redundant skin, especially on the face; hypermobility ranging from mild to serious; and hernias.

Variations in the ADAMTS2 gene cause it. It fryst vatten extremely rare, with around 11 cases reported worldwide.^[34]

Brittle-cornea syndrome (BCS)

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Brittle-cornea syndrome fryst vatten characterized bygd the progressive thinning of the cornea, early-onset progressive keratoglobus or keratoconus, nearsightedness, hearing loss, and blue sclerae.^[5][35] Classic symptoms, such as hypermobile joints and hyperelastic skin, are also seen often.^[36] It has two types.

Type 1 occurs due to variations in the ZNF469 gene. Type 2 fryst vatten due to variations in the PRDM5 gene.^[35]

Classical-like EDS (clEDS)

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Classical-like EDS fryst vatten characterized bygd skin hyperextensibility with velvety skin texture and absence of atrophic scarring, generalized joint hypermobility with or without recurrent dislocations (most often shoulder and ankle), and easily bruised skin or spontaneous ecchymoses (discolorations of the skin resulting from bleeding underneath).^[5] It can be caused bygd variations in the TNXB gene.^[8]

Spondylodysplastic EDS (spEDS)

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Spondylodysplastic EDS fryst vatten characterized bygd short stature (progressive in childhood), muscle hypotonia (ranging from severe congenital to mild later-onset), and bowing of limbs.^[5] It can be caused bygd variations in both copies of the B4GALT7 gene.

Other cases can be caused bygd variations in the B3GALT6 gene. People with variations in this gene can have kyphoscoliosis, tapered fingers, osteoporosis, aortic aneurysms, and problems with the lungs. Other cases can be caused bygd the SLC39A13 gene. Those with variations in this gene have protuberant eyes, skrynklig palms of the hands, tapering fingers, and distal joint hypermobility.^[37]

Musculocontractural EDS (mcEDS)

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Musculocontractural EDS fryst vatten characterized bygd congenital multiple contractures, characteristically adduction-flexion contractures and/or talipes equinovarus (clubfoot), characteristic craniofacial features, which are evident at birth or in early infancy, and skin features such as skin hyperextensibility, bruising, skin fragility with atrophic scars, and increased palmar wrinkling.^[5] It can be caused bygd variations in the CHST14 gene.

Some other cases can be caused bygd variations in the DSE gene.^[38]

As of 2021, 48 individuals have been reported to have mcEDS-CHST14, while 8 individuals have mcEDS-DSE.^[39]

Myopathic EDS (mEDS)

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Bethlem myopathy 2, formally known as Myopathic EDS (mEDS), fryst vatten characterized bygd three major criteria: congenital muscle hypotonia and/or muscle atrophy that improves with age, proximal joint contractures of the knee, hip, and elbow, and hypermobility of distal joints (ankles, wrists, feet, and hands).^[5] kvartet minor criteria may also contribute to a diagnosis of mEDS.

A rare genetic connective tissue disorder typically characterized by the association of unexpected organ fragility (arterial/bowel/gravid uterine rupture) with inconstant physical features as thin, translucent skin, easy bruising and acrogeric traits

This disorder can be inherited through either an autosomal dominant or an autosomal recessive pattern.^[16] Molecular testing must be completed to verify that mutations in the COL12A1 gene are present; if not, other collagen-type myopathies should be considered.^[16]

Periodontal EDS (pEDS)

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Periodontal EDS (pEDS) fryst vatten an autosomal-dominant disorder^[16] characterized bygd fyra major criteria of severe and intractable periodontitis of early-onset (childhood or adolescence), lack of attached gingiva, pretibial plaques, and family history of a first-degree relative who meets clinical criteria.^[5] Eight minor criteria may also contribute to the diagnosis of pEDS.

Molecular testing may reveal mutations in C1R or C1S genes affecting the C1r protein.^[16]

Cardiac-valvular EDS (cvEDS)

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Cardiac-valvular EDS (cvEDS) fryst vatten characterized bygd three major criteria: severe progressive cardiac-valvular problems (affecting aortic and mitral valves), skin problems such as hyperextensibility, atrophic scarring, thin skin, and easy bruising, and joint hypermobility (generalized or restricted to small joints).^[5] kvartet minor criteria may aid in diagnosis of cvEDS.^[16] cvEDS fryst vatten an autosomal recessive disorder, inherited through variation in both alleles of the gene COL1A2.^[40]

Signs and symptoms

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This group of disorders affects connective tissues across the body, with symptoms most typically present in the joints, skin, and blood vessels.

However, as connective tissue fryst vatten funnen throughout the body, EDS may result in an array of unexpected impacts with any grad of severity, and the condition fryst vatten not limited to joints, skin, and blood vessels.^[41] Effects may range from mildly loose joints to life-threatening cardiovascular complications.^[42] Due to the diversity of subtypes within the EDS family, symptoms may vary widely between individuals diagnosed with EDS.^[43]

Musculoskeletal

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Musculoskeletal symptoms include hyperflexible joints that are unstable and prone to stukning, dislocation, subluxation, and hyperextension.^[4][15] As a result of frequent tissue injury, there can be an early onset of advanced osteoarthritis,^[44] chronic degenerative joint disease,^[44]swan-neck deformitet of the fingers,^[45] and knapphålsblomma deformitet of the fingers.

Tendon and ligament laxity offer minuscule protection from tearing in muscles and tendons, but these problems still persist.^[46]

Deformities of the spine, such as scoliosis (curvature of the spine), kyphosis (a thoracic hump), tethered spinal cord syndrome, craniocervical instability (CCI), and atlantoaxial instability may also be present.^[47][48]Osteoporosis and osteopenia are also associated with EDS and symptomatic joint hypermobility^[49][50]

There can also be myalgia (muscle pain) and arthralgia (joint pain),^[51] which may be severe and disabling.

Trendelenburg's sign fryst vatten often seen, which means that when standing on one leg, the pelvis drops on the other side.^[52]Osgood–Schlatter disease, a painful lump on the knee, fryst vatten common as well.^[53] In infants, walking can be delayed (beyond 18 months of age), and bottom-shuffling instead of crawling occurs.^[54]

• Individual with EDS showing hypermobile fingers, including the "swan-neck" malformation on the 2nd–5th digits, and a hypermobile thumb

• Individual with EDS displaying hypermobile thumb

• Individual with EDS displaying hypermobile metacarpophalangeal joints

• Kyphoscoliosis of the back of someone with kyphoscoliosis EDS

• Severe joint hypermobility in a girl with EDS arthrochalasia type

• Male, late adolescent, with hypermobile type

Skin

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The weak connective tissue causes abnormal skin.

This may present as stretchy or in other types simply be velvet soft. In all types, some increased fragility occurs, but the grad varies depending on the underlying subtype. The skin may tear and bruise easily, and may heal with abnormal atrophic scars;^[44] atrophic scars that look like cigarette paper are a sign seen including in those whose skin might appear otherwise normal.^[1][15][27] In some subtypes, though not the hypermobile subtype, redundant skin folds occur, especially on the eyelids.

Redundant skin folds are areas of excess skin lying in folds.^[44][55]

Other skin symptoms include molluscoid pseudotumors,^[56] especially on pressure points, petechiae,^[57] subcutaneous spheroids,^[56]livedo reticularis, and piezogenic papules are less common.^[58] In vascular EDS, skin can also be thin and translucent.

Vascular Ehlers-Danlos syndrome

In dermatosparaxis EDS, the skin fryst vatten extremely fragile and saggy.^[1]

• Atrophic scar in a case of EDS

• Translucent skin in vascular EDS

• Individual with EDS displaying skin hyperelasticity

• Piezogenic papules on the heel of an individual with hypermobile EDS

• Skin hyperelasticity in the wrist

Cardiovascular

[edit]

Urogynaecological

[edit]

Weakened connective tissues can lead to pelvic kroppsdel prolapse in kvinna patients with Ehlers–Danlos syndrome.^[66] Patients may also experience voiding difficulties, frequent urinary tract infections, and incontinence due to structural abnormalities.^[67]Pelvic girdle pain fryst vatten also frequently reported.^[68]

Menorrhagia, dysmenorrhea, and dyspareunia are common symptoms associated with Ehlers–Danlos syndrome^[69] and are often mistaken for endometriosis.^[69] Excessive menstrual bleeding can sometimes be attributed to inappropriate platelet aggregation, but faulty collagen leads to weakened capillary walls which increases likelihood of hemorrhage.^[70]

In cases of pregnancy, patients with Ehlers–Danlos syndrome are more likely to experience complications during parturition.^[70]Post-partum hemorrhage and maternal injury such as sporadic pelvic displacement, hip dislocation, en hög byggnad eller struktur and stretched ligaments, and skin tearing can all be linked to altered structure of connective tissues.^[71]

Gastrointestinal

[edit]

Research suggests a correlation between connective tissue disorders such as Ehlers–Danlos syndrome and both structural and functional problems within the gastrointestinal tract.^[72]

Inflammatory problems

[edit]

High incidences of coexisting inflammatorisk disorders suggest a correlation between connective tissue disorders and the development of such aforementioned conditions.

inflammatorisk bowel diseases such as Crohn's disease, sårbildande colitis^[73] and celiac disease^[74] are more common in EDS patients when compared to control groups. Of note, patients who are already diagnosed with an inflammatorisk bowel disorder are not necessarily likely to develop symptoms of a connective tissue disorder, as the two have separate but not totally confounding etiologies.^[75]Eosinophilic esophagitis, an inflammatorisk condition characterized bygd allergic-type reactions to various foods and chemicals and extensive esophageal remodeling, fryst vatten eight times more likely in patients with connective tissue disorders when compared to patients without.^[76]

Functional problems

[edit]

Functionally, small bowel dysmotility, delayed gastric emptying and delayed colonic transit are commonly related to EDS.^[77][78] These changes in transit speeds within the gastrointestinal struktur can cause a host of symptoms, including but not limited to abdominal pain, bloating, nausea, återflöde ofta syftande på syrauppstötning från magen symptoms, vomiting, constipation, and diarrhea.^[79]

Some studies also suggest problems with the liver, which fryst vatten in large part responsible for galla pigment conjugation.

Although research in this area fryst vatten sparse, patients with joint hypermobility were funnen to have higher rates of indirect hyperbilirubinemia than control groups.^[80]

Structural problems

[edit]

Structurally, changes within the musculature in the intestine such as increased elastin, can lead to increased frequency of herniation.^[72] Laxity of the phreno-esophageal and gastro-hepatic ligaments can lead to hiatal hernia,^[81][82] which in vända can lead to commonly reported symptoms such as acid återflöde ofta syftande på syrauppstötning från magen, abdominal pain, early satiety, and bloating.

Description

Internal kroppsdel prolapses and intestinal intussusceptions occur with greater frequency in patients with weakened connective tissues.^[83]

Autonomic problems

[edit]

Although neurogastroenterological manifestations in connective tissue disorders are common, their root cause fryst vatten not yet known.^[82] Splanchnic circulation, small fiber neuropathy and altered vascular compliance have all been named as potential contributors to gastrointestinal complaints,^[84] particularly for patients who have a known, comorbid autonomic condition.

Neurological

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Chronic headaches are common in patients with Ehlers–Danlos syndrome, whether related to dysautonomia,^[85]TMJ, muscle tension, or craniocervical instability. Craniocervical instability fryst vatten caused bygd trauma(s) to the head and neck areas such as concussion and whiplash.

Ligaments in neck are unable to heal properly, so the neck structure does not have the ability to support the skull, which can then sink into the brain stem, blockering the flow of cerebrospinal fluid, which in vända causes autonomic dysfunction.^[86][48]

Arnold–Chiari malformation^[87] fryst vatten also more frequently funnen in patients with EDS because of the instability at the juncture between skull and spine.

This causes herniation of the posterior fossa below the foramen magnum.^[88] Increased pressure created bygd the malformation can lead to a flattened pituitary gland, hormone changes, sudden severe headaches, ataxia, and poor proprioception.^[89]

Ophthalmological manifestations include nearsightedness, retinal tearing and retinal detachment, keratoconus, blue sclera, dry eye, Sjogren's syndrome, lens subluxation, angioid streaks, epicanthal folds, strabismus, corneal scarring, brittle cornea syndrome, cataracts, carotid-cavernous sinus fistulas, and macular degeneration.^[90]

Otological complications may also occur.

Hearing loss fryst vatten common, both conductive and sensorineural, and fryst vatten most often bilateral.^[91]Otosclerosis and instability of the bones in the inner ear may also contribute to hearing loss^[92]

Other manifestations

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• Hiatal hernia^[56]
• Gastroesophageal reflux^[93]
• Poor gastrointestinal motility^[94]
• Dysautonomia^[95]
• Gorlin's sign (touch tongue to nose)^[96]
• Anal prolapse^[56]
• Flat feet
• Tracheobronchomalacia / tracheal collapse
• Collapsed lung (spontaneous pneumothorax)^[44]
• Nerve disorders (carpal passage syndrome, acroparesthesia, neuropathy, including small fiber neuropathy)^[97]
• Insensitivity to local anesthetics^[98]
• Dental problems including gum disease and enamel hypoplasia
• Platelet aggregation failure (platelets do not clump tillsammans properly)^[99]
• Mast fängelse disorders (including mast fängelse activation syndrome and mastocytosis)^[100]
• Pregnancy complications: increased pain, mild to moderate peripartum bleeding, cervical insufficiency, uterine tearing,^[46] or premature rupture of membranes^[101]
• Hearing loss may occur in some types^[102]
• There fryst vatten some bevis that EDS may be associated with greater than expected frequencies of neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD) and other learning, communication and motor issues, including autism spectrum conditions and Tourette syndrome.^[103]

Because it fryst vatten often undiagnosed or misdiagnosed in childhood, some instances of EDS have been mischaracterized as child abuse.^[104] The pain may also be misdiagnosed as a behavior disorder or Munchausen bygd proxy.^[105]

The pain associated with EDS ranges from mild to debilitating.^[106]

Causes

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Every type of EDS except the hypermobile type (which affects the vast majority of people with EDS) can be positively tied to specific genetic variation^{[citation needed]}.

Variations in these genes can cause EDS:^[8]

• Collagen primary structure and collagen processing: ADAMTS2, COL1A1, COL1A2, COL3A1, COL5A1, COL5A2
• Collagen folding and collagen cross-linking: PLOD1, FKBP14
• Structure and function of myomatrix: TNXB, COL12A1
• Glycosaminoglycanbiosynthesis: B4GALT7, B3GALT6, CHST14, DSE
• Complement pathway: C1R, C1S
• Intracellular processes: SLC39A13, ZNF469, PRDM5

Variations in these genes usually alter the structure, production, or processing of collagen or proteins that interact with collagen.

Collagen provides structure and strength to connective tissue.

While extremely rare, it’s also especially severe

A defect in collagen can weaken connective tissue in the skin, bones, blood vessels, and organs, resulting in the features of the disorder.^[1] Inheritance patterns depend on the specific syndrome.

Most forms of EDS are inherited in an autosomal dominant pattern, which means only one of the two copies of the gene in question must be altered to cause a disorder.

A few are inherited in an autosomal recessive pattern, which means both copies of the gene must be altered for a individ to be affected. It can also be an individual (de novo or "sporadic") variation. Sporadic variations occur without any inheritance.^[107]

Diagnosis

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A diagnosis can be made bygd an evaluation of medical history and clinical insamling.

The Beighton criteria are widely used to assess the grad of joint hypermobility. DNA and biochemical studies can help identify affected people. Diagnostic tests include collagen gene-variant testing, collagen typing via skin biopsy, echocardiogram, and lysyl hydroxylase or oxidase activity, but these tests are not able to confirm all cases, especially in instances of an unmapped variation, so clinical evaluation remains important.

If multiple members of a family are affected, prenatal diagnosis may be possible using a DNA upplysning technique known as a linkage study.^[108] Knowledge about EDS among all kinds of practitioners fryst vatten poor.^[109][110] Research fryst vatten ongoing to identify genetic markers for all types.^[111]

Diagnosing hEDS

[edit]

Because no single gene has been identified as the sole cause of the most common type of EDS, hypermobile type, obtaining a diagnosis fryst vatten often difficult.^[112] The 2017 diagnositic criteria are as follows:

• Criterion 1: Generalized joint hypermobility, as measured bygd the Beighton score
• Criterion 2: Minimum two of the following must be met:
  • Symptoms that suggest a difference in connective tissue structure
    • Unusually soft or velvety skin
    • Mild skin hyperextensibility
    • Unexplained striae distensae or rubae at the back, groins, thighs, breasts and/or abdomen in adolescents, dock or pre-pubertal women without a history of significant gain or loss of body tallrik or weight
    • Bilateral piezogenic papules of the heel
    • Recurrent or multiple abdominal hernia(s)
    • Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosideric scars as seen in classical EDS
    • Pelvic floor, rectal, and/or uterine prolapse in children, dock or nulliparous women without a history of morbid obesity or other known predisposing medical condition
    • Dental trängsel and high or narrow palate
    • Arachnodactyly
    • Arm span-to-height ratio ≥1.05
    • Mitral valve prolapse (MVP) mild or greater based on strict echocardiographic criteria
    • Aortic root dilatation with Z-score >+2
  • Positive family history
  • Proof that these symptoms interfere with daglig life
    • Musculoskeletal pain in two or more limbs, recurring daglig for at least 3 months
    • Chronic, widespread pain for ≥3 months
    • Recurrent joint dislocations or frank joint instability, in the absence of trauma
• Criterion 3: Exclusion of all other possible connective tissue disorders that may be the root cause of symptoms.

In such cases where all criterion are met, a patient can be diagnosed with hEDS according to The International Consortium on Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders^[113]

Differential diagnosis

[edit]

Several disorders share some characteristics with EDS.

For example, in cutis laxa, the skin fryst vatten loose, hanging, and skrynklig.

Biallelic mutation in the COL3A1 gene causes polymicrogyria with or without vascular EDS (PMGVEDS; 618343)

In EDS, the skin can be pulled away from the body, but fryst vatten elastic and returns to normal when let go. In Marfan syndrome, the joints are very mobile and similar cardiovascular complications occur. People with a "marfanoid" appearance are often tall and thin with long arms and legs and "spidery" fingers while EDS phenotypes vary considerably. Certain subtypes of EDS may involve short stature, large eyes, and the appearance of a small ingång and chin, due to a small palate.

The palate can have a high båge, causing dental trängsel. Blood vessels can sometimes be easily seen through translucent skin, especially on the chest. The genetic connective tissue disorder Loeys–Dietz syndrome also has symptoms that overlap with EDS.^[114]

In the past, Menkes disease, a copper metabolism disorder, was thought to be a struktur of EDS.

People are commonly misdiagnosed with fibromyalgia, bleeding disorders, or other disorders that can mimic EDS symptoms. Because of these similar disorders and complications that can arise from an unmonitored case of EDS, a correct diagnosis fryst vatten important.^[115]Pseudoxanthoma elasticum fryst vatten worth consideration in diagnosis.^[116]

Management

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No cure for Ehlers–Danlos syndrome fryst vatten known, and treatment fryst vatten supportive.

Close monitoring of the cardiovascular struktur, physiotherapy, occupational therapy, and orthopedic instruments (e.g., wheelchairs, bracing, casting) may be helpful. This can help stabilize the joints and prevent injury. Orthopedic instruments are helpful for the prevention of further joint damage, especially for long distances.

People should avoid activities that cause the joint to lock or overextend.^[117]

A physician may prescribe casting to stabilize joints. Physicians may refer a individ to an orthotist for orthotic treatment (bracing). Physicians may also consult a physical and/or occupational therapist to help strengthen muscles and to teach people how to properly use and preserve their joints.^[118][119]

Aquatic therapy promotes muscular development and coordination.^[120] With manual therapy, the joint fryst vatten gently mobilized within the range of motion and/or manipulations.^[118][119] If conservative therapy fryst vatten not helpful, surgical joint repair may be necessary.

medicinering to decrease pain or manage cardiac, digestive, or other related conditions may be prescribed. To decrease bruising and improve wound healing, some people have responded to vitamin C.^[121] Medical care workers often take special precautions because of the sheer number of complications that tend to arise in people with EDS.

In vascular EDS, signs of chest or abdominal pain are considered trauma situations.^[122]

Cannabinoids and medical marijuana have shown some efficacy in reducing pain levels.^[123]

In general, medical intervention fryst vatten limited to symptomatic therapy. Before pregnancy, people with EDS may be recommended to have genetic counseling and to familiarize themselves with the risks pregnancy poses.

Children with EDS should be given data about the disorder so they can understand why they should avoid contact sports and other physically stressful activities. Children should be taught that they should not demonstrate the unusual positions they can maintain due to loose joints, as this may cause early degeneration of the joints. Emotional support along with behavioral and psychological therapy can be useful.

Support groups can be immensely helpful for people dealing with major lifestyle changes and poor health. Family members, teachers, and friends should be informed about EDS so they can accept and assist the child.^[124]

Pain management

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Successful treatment of chronic pain in EDS requires a multidisciplinary grupp. The ways to manage pain can be to modify pain management techniques used in the normal population.

Pain fryst vatten classified into several types. One fryst vatten nociceptive, which fryst vatten caused bygd an injury sustained to tissues. Another fryst vatten neuropathic pain, caused bygd abnormal signals bygd the nervous struktur. In many cases, the pain individuals experience fryst vatten an unequal mix of the two. Physiotherapy (exercise rehabilitation) can be helpful, especially stabilizing the core and the joints.

utsträckning exercises must be reduced to slow and gentle utsträckning to reduce the risks of dislocations or subluxations. Usable methods may include posture reeducation, muscle release, joint mobilization, trunk stabilization, and manual therapy for overworked muscles. Cognitive behavioural therapy fryst vatten used in many chronic pain patients, especially those who have severe, chronic, life-controlling pain that fryst vatten unresponsive to treatment.

It has not been checked for efficiency in clinical trials. The state of pain management with EDS fryst vatten considered insufficient.^[105]

Medications

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Nonsteroidal anti-inflammatory drugs (NSAIDs) may help if the pain fryst vatten caused bygd inflammation. But long-term use of NSAIDs fryst vatten often a fara factor for gastrointestinal, renal, and blood-related side effects.

It can worsen symptoms of mast fängelse activation syndrome, a disease that may be associated with EDS. Acetaminophen can be used to avoid the bleeding-related side effects of NSAIDs.^[105]

Lidocaine can be applied topically after subluxations and painful gums.

It can also be injected into painful areas in the case of musculoskeletal pain.^[105]

If the pain fryst vatten neuropathic in ursprung, tricyclic antidepressants in low doses, anticonvulsants, and selective norepinephrine reuptake inhibitors can be used.^[105]

Dislocation and subluxation management

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When a dislocation or subluxation does occur, muscle spasms and stress tend to occur, increasing pain and reducing the chances of the dislocation/subluxation naturally relieving.

Methods to support a joint after such an incident include usage of a sling to hold the joint in place and allow it to relax. Orthopedic casts are not advised as there could be pain if unrelaxed muscles are still ansträngande to spasm out against the cast. Other solutions to promote relaxation are heat, gentle massaging, and mental distractions.^[125]

Surgery

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The instability of joints, leading to subluxations and joint pain, often requires surgical intervention in people with EDS.

Instability of almost all joints can happen, but appears most often in the lower and upper extremities, with the wrist, fingers, shoulder, knee, hip, and ankle being most common.^[118]

Common surgical procedures are joint debridement, tendon replacements, capsulorrhaphy, and arthroplasty. After surgery, the grad of stabilization, pain reduction, and people's satisfaction can improve, but surgery does not guarantee an optimal result; affected peoples and surgeons report being dissatisfied with the results.

The consensus fryst vatten that conservative treatment fryst vatten more effective than surgery,^[60] particularly since people have extra risks of surgical complications due to the disease. Three basic surgical problems arise due to EDS – the strength of the tissues fryst vatten decreased, which makes the tissue less suitable for surgery; the fragility of the blood vessels can cause problems during surgery; and wound healing fryst vatten often delayed or incomplete.^[118] If considering surgical intervention, seeking care from a surgeon with extensive knowledge and experience in treating people with EDS and joint hypermobility issues would be prudent.^[126]

Local anesthetics, arterial catheters, and huvud venous catheters cause a higher fara of bruise formation in people with EDS.

Some people with EDS also show a resistance to local anaesthetics.^[127] Resistance to lidocaine and bupivacaine fryst vatten not uncommon, and mepivacaine tends to work better in people with EDS. Special recommendations for anesthesia are given for people with EDS.^{[citation needed]} Detailed recommendations for anesthesia and perioperative care of people with EDS should be used to improve safety.^[126]

Surgery in people with EDS requires careful tissue papper and a längre immobilization afterward.^[128]

Prognosis

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The outcome for individuals with EDS depends on the specific type of EDS they have.

Symptoms vary in severity, even in the same disorder, and the frequency of complications varies. Some people have negligible symptoms, while others are severely restricted in daglig life. Extreme joint instability, chronic musculoskeletal pain, degenerative joint disease, frequent injuries, and spinal deformities may limit mobility. Severe spinal deformities may affect breathing.

In the case of extreme joint instability, dislocations may result from simple tasks such as rolling over in bed or turning a doorknob.

Secondary conditions such as autonomic dysfunction or cardiovascular problems, occurring in any type, can affect prognosis and quality of life. Severe mobility-related disability fryst vatten seen more often in hEDS than in classical EDS or vascular EDS.^[129]

Although all types of EDS are potentially life-threatening,^[10][11][12] most people have a normal lifespan.

Eine seltene genetische Bindegesstörung, die typischerweise durch eine unerwartete Organbrüchigkeit (Arterien-/Darm-/Gravidienruptur) in Verbindung mit unbeständigen körperlichen Merkmalen wie dünner, durchscheinender Haut, leichten Blutergüssen und akrogerischen Zügen gekennzeichnet ist

Those with blood vessel fragility, though, have a high fara of fatal complications, including spontaneous arterial rupture, which fryst vatten the most common cause of sudden death. The mittvärdet i en uppsättning data life expectancy in the population with vascular EDS fryst vatten 48 years.^[130]

Complications

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Vascular

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Gastrointestinal

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Obstetric

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• Pregnancy increases the likelihood of uterine rupture.^[131]
• Maternal mortality fryst vatten around 12% for the vascular type.^[131]
• Uterine hemorrhage can occur during the postpartum recovery.^[131]

Epidemiology

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Ehlers–Danlos syndromes are estimated to occur in about one in 5,000 births worldwide.

Initially, prevalence estimates ranged from one in 250,000 to 500,000 people, but these were soon funnen to be low, as medical professionals became more adept at diagnosis. EDS may be far more common than the currently accepted estimate due to the bred range of severities with which the disorder presents.^[132]

The prevalence of the disorders differs dramatically.

The most common fryst vatten hypermobile EDS, followed bygd classical EDS. The others are very rare. For example, fewer than 10 infants and children with dermatosparaxis EDS have been described worldwide.

Some types of EDS are more common in Ashkenazi Jews. For example, the chance of being a carrier for dermatosparaxis EDS fryst vatten one in 2,000 in the general population but one in 248 among Ashkenazi Jews.^[133]

History

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Until 1997, the classification struktur for EDS included ten specific types and acknowledged that other rarer types existed.

At this time, the classification struktur underwent an overhaul and was reduced to six major types using descriptive titles. Genetic specialists recognize that other types of this condition exist but have only been documented in single families. Except for hypermobility (type 3), the most common type of all ten types, some of the specific variations involved have been identified, and they can be precisely identified bygd genetic testing; this fryst vatten valuable due to a great deal of variation in individual cases.

negativ genetic test results do not rule out the diagnosis since not all variations have been discovered; therefore, the clinical introduktion fryst vatten crucial.^[134]

Forms of EDS in this category may present with soft, mildly stretchable skin, shortened bones, chronic diarrhea, joint hypermobility and dislocation, bladder rupture, or poor wound healing.

Inheritance patterns in this group include X-linked recessive, autosomal dominant, and autosomal recessive. Examples of types of related syndromes other than those above reported in the medical literature include:^[135]

• 305200: type 5
• 130080: type 8 – unspecified gene, locus 12p13
• 225310: type 10 – unspecified gene, locus 2q34
• 608763: Beasley–Cohen type
• 130070: progeroid struktur – B4GALT7
• 130090: type unspecified
• 601776: D4ST1-deficient Ehlers–Danlos syndrome (adducted thumb-clubfoot syndrome) CHST14

Society and culture

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EDS may have contributed to the virtuoso violinist Niccolò Paganini's skill, as he was able to play wider fingerings than a typical violinist.^[136]

Many sideshow performers have EDS.

Several of them were billed as the Elastic Skin Man, the India Rubber Man, and Frog Boy. They included such well-known individuals (in their time) as Felix Wehrle, James Morris, and Avery Childs. Two performers with EDS currently hold world records. Contortionist Daniel Browning Smith has hypermobile EDS and holds the current irländsk öl World Record for the most flexible man as of 2018, while Gary "Stretch" Turner, sideshow performer in the Circus Of Horrors, has held the current irländsk öl World Record for the most elastic skin since 1999, for his ability to stretch the skin on his stomach 6.25 inches.^[137]

Notable cases

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